In our lab we mainly focus on drug discovery and development of various therapeutic targets such as Neurodegenerative Disorders (ALS, Alzheimer’s and Parkinson’s disease etc.), and Inflammatory Disorders (COPD, RA), GPCRs for the treatment of Diabetic Disorders (NIDDM), Cancer, Cardiovascular Disorders, Obesity, and other Metabolic Disorders.   We are also very interested in research and development with an emphasis in design and synthesis of both symmetric and asymmetric orga...

Novel Ghrelin Antagonists for treatment of Obesity. Novel Sigma-1 Receptor Agonists for treatment of Neurodegenerative Diseases. Novel A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s disease and SAR of the new Preladenant analogs. Discovery of novel Excitatory Amino Acid Transporter-2 (EAAT2) modulators for the treatment of ALS and other neurodegenerative disorders. Regulation of cancer cell metabolism: Targeting cancer metabolism as an alternative therapeutic trea...

Synthesis of Novel Methyl Jasmonate Derivatives and Evaluation of Their Biological Activity in Various Cancer Cell Lines; Bilgesu Onur Sucua, Ozgecan Savlug Ipek, Sukran Ozdatli Kurtulus, Busra Emine Yazici, Nihal Karakas, and Mustafa Guzel. Bioorganic Chemistry, (2019). DOI: https://doi.org/10.1016/j.bioorg.2019.103146 “Novel Strategies for the Synthesis of A2A Adenosine Receptor Antagonist Analogs”; Şükran Özdatlı, Hanife Pekel, Bilgesu Onur Sucu, and Mustafa Guzel; Tetrahedron Letters,...

In our lab we mainly focus on drug discovery and development of various therapeutic targets such as Neurodegenerative Disorders (ALS, Alzheimer’s and Parkinson’s disease etc.), and Inflammatory Disorders (COPD, RA), GPCRs for the treatment of Diabetic Disorders (NIDDM), Cancer, Cardiovascular Disorders, Obesity, and other Metabolic Disorders.