Patents & Publications

Posted on by IBraheem Mostafa ZA
  • Synthesis of Novel Methyl Jasmonate Derivatives and Evaluation of Their Biological Activity in Various Cancer Cell Lines; Bilgesu Onur Sucua, Ozgecan Savlug Ipek, Sukran Ozdatli Kurtulus, Busra Emine Yazici, Nihal Karakas, and Mustafa Guzel. Bioorganic Chemistry, (2019). DOI: https://doi.org/10.1016/j.bioorg.2019.103146
  • “Novel Strategies for the Synthesis of A2A Adenosine Receptor Antagonist Analogs”; Şükran Özdatlı, Hanife Pekel, Bilgesu Onur Sucu, and Mustafa Guzel; Tetrahedron Letters, volume: 59, number: 3, (2019), manuscript in preparation.
  • “Antifungal and Antibacterial Activity of Some Marine Invertebrates from Turkish Coastlines”; Ayse Esra Karadag, Hajar Heydari, Ismail Korpe, Belma Konuklugil, Betul Giray, and Mustafa Guzel; Frontiers in Microbiology, 2019, manuscript submitted.
  • “Novel Heteroaryl-Pyrazole Derivative Molecules and Their Use as Antigungal Agents”; Hatice Baspinar Kucuk, Mustafa Guzel, Ayse Esra Karadag, Betül Giray, and Ozgecan Savlug Ipek; TR Patent, Istanbul Medipol University, Istanbul, Patent No: 2019/06570, 02/05/2019.
  • “Novel Synthetic Approaches for Bisnaphthalimidopropyl (BNIP) Derivatives as Anti-Parasitic Agents for the Treatment of Leishmaniasis”; Elif Keskin, Mehmet Hikmet Ucisik, Bilgesu Onur Sucu, and Mustafa Guzel; Molecules, Volume: 24, 2019, manuscript submitted.
  • “Identification and in-vitro Bioactivity Screening of Some Marine-Derived Fungi from Turkish Coastlines”; Hajar Heydari, Aslı Koc, Belma Konuklugil, Betul Giray, Ayse Esra Karadag, and Mustafa Guzel; Frontiers in Microbiology, 2019, manuscript submitted.
  • “Synthesis of Novel Methyl Jasmonate Derivatives and Evaluation of Their Biological Activity in Various Cancer Cell Lines”; Bilgesu Onur Sucua, Ozgecan Savlug Ipek, Sukran Ozdatli Kurtulus, Busra Emine Yazici, Nihal Karakas, and Mustafa Guzel; Bioorganic Chemistry, Volume: 92, 2019, manuscript submitted.
  • “Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model”; Raziye Piranlioglu, EunMi Lee, Maria Ouzounova, Roni J. Bollag, Alicia H. Vinyard, Ali S. Arbab, Daniela Marasco, Mustafa Guzel, John K. Cowell, Muthushamy Thangaraju, Ahmed Chadli, Khaled A. Hassan, Max S. Wicha, Esteban Celis and Hasan Korkaya; Nature Communications, volume: 10, number: 1410, pages: 1-13, 2019. doi: 10.1038/s41467-019-09015-1.
  • “The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20”; Eunmi Lee, Maria Ouzounova, Raziye Piranlioglu, Minh Thu Ma, Mustafa Guzel, Daniela Marasco, Ahmed Chadli, Jason E. Gestwicki, John K. Cowell, Max S. Wicha, Khaled A. Hassan, and Hasan Korkaya; Oncogene, volume: 37, number: 36, pages: 1-14, 2019. doi: 10.1038/s41388-018-0472-0.
  • “Heterobivalent Ligands Suitable for Use in The Treatment of Parkinson’s Disease”; Ozge Sensoy, Mustafa Guzel, Bilal Ersen Kerman, Neslihan Ustundag Okur, Samman Mansoor, Essam Alshahaby, Elif Keskin, Serdar Durdagi, and Gulru Kayik; WO Patent, Istanbul Medipol University and Bahcesehir University, Istanbul, Patent No: WO2019004970, 03/01/2019.
  • “Novel Bisnapthalimidopropyl (BNIP) Derivatives as Active Pharmaceutical Ingredients”; Mustafa Guzel, Mehmet Hikmet Ucisik, Fikrettin Sahin, Elif Keskin, and Zeynep Islek; TR Patent, Istanbul Medipol University, and Yeditepe University, Istanbul, Patent No: 2018/20740, 27/12/2018.
  • “Development of Novel Caffeic Acid Phenetyl Ester (CAPE) Analogs as Anticancer Agents and Determination of Their Biological Activities”; Mustafa Guzel, Nihal Karakas, Ozgecan Savlug Ipek, Bilgesu Onur Sucu, Elif Beyza Koc, Melike Aybala Guzel, Irem Ozturk, Ibrahim Serkut Tosyalı, and Rabia Yilmaz; TR Patent, Istanbul Medipol University, and Uskudar University, Istanbul, Patent No: 2018/15127, 11/10/2018.
  • “Methyl Jasmonate Derivatives as Possible Drug Candidates for Use in Treatment of Cancer”; Mustafa Guzel, Sukran Ozdatli Kurtulus, Ozgecan Savlug, and Bilgesu Onur Sucu; WO Patent, Istanbul Medipol University, Istanbul, Patent No: PCT/TR2018/050522, 25/09/2018.
  • “Original Drug Molecules for The Treatment of Parasitic and Neoplastic Diseases and Methods for Preparation Thereof”; Mehmet Hikmet Ucisik, Mustafa Guzel, Elif Keskin, Bilgesu Onur Sucu, and Aslihan Golcuk; WO Patent, Istanbul Medipol University, Istanbul, Patent No: WO2018106200, 14/06/2018.
  • “Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof”; Adnan MM Mjalli, Dharma Rao Polisetti, Jareer Nabeel Kassis, Matthew J Kostura, Mustafa Guzel, Otis Clinton Attucks, Robert Carl Andrews, Samuel Victory, and Suparna Gupta; US Patent, vTv Therapeutics, High Point, NC, Patent Application # 16007532, 10/11/2018.
  • “Tricyclic Compounds As Modulators Of Tnf-Alpha Synthesis And As Pde4 Inhibitors”; Adnan MM Mjalli, Bapu Gaddam, Dharma Rao Polisetti, Matthew J Kostura, and Mustafa Guzel; US Patent, vTv Therapeutics, High Point, NC, Patent Application # 15800794, 15/3/2018.
  • “Do neuropathy and hypertension associated with increased risk of hearing loss among type 2 diabetic patients?”; Abdulbari Bener, Lütfü Hanoglu, Hakan Cincik, Mustafa Güzel ,Mustafa Öztürk, Ralph A. DeFronzo, and Muhammad Abdul-Ghani; International Journal of Neuroscience and Behavior Studies, volume:1, no:2, pages: 41-46, 2017.
  • “Essential Parameters and Risk Factors of the Patients for Diabetes Care and Treatment“; Abdulbari Bener, Fatma E. Keskin, Eda M. Kurtulus, Mustafa Guzel, Elif I. Çekirdekçi, Pınar Kadıoğlu, Dildar Konukoğlu, and Mustafa Öztürk; Diabetes & Metabolic Syndrome: Clinical Research &Reviews, volume: 1, number:1, page: S315-S320, 2017. doi: http://doi.org/10.1016/j.dsx.2017.03.008.
  • “Gender Satisfaction among Type 2 Diabetes Patients: A Comparison between Intensive Diets, Lifestyle Intervention with Medication Controlled Management”; Abdulbari Bener, Abdulla O. A. A. Al-Hamaq, Funda Çatan, Kaleem U. Rajput and Mustafa Guzel; British Journal of Medicine & Medical Research, volume: 18, number: 7, p: 1-13, 2016, doi: 10.9734/BJMMR/2016/29418.
  • “Inhibitors of Hexokinase and Methods of Use Thereof”; Adnan M.M. Mjalli, Bapu Gaddam, Devi Reddy Gohimukkula, Dharma Rao Polisetti, Mohan Rao, Mustafa Guzel, Nidhi Singh, Rima Hajjo, Robert Carl Andrews, Rongyuan Xie, Santhosh Kalpathy, Soumya Prakash Sahoo, and Stephen Thomas Davis; vTv Therapeutics, High Point, NC, 2016, Patent # WO 2016196890 A1 (PCT/US2016/035663).
  • “The Role and Importance of Medicinal Chemistry in Novel Drug Discovery and Development“; Mustafa Guzel, ve Sezgin Kiren; Turkish Clinics, Turkiye Klinikleri J Pharm Sci 2016;5(1):36-45, 2016. doi: 10.5336/pharmsci.2015-48211.
  • “Substituted azoanthracene derivatives and intermediates for preparation thereof”; Adnan MM Mjalli, Christopher Behme, Daniel P Christen, Devi Reddy Gohimukkula, Dharma Rao Polisetti, James C Quada Jr, Jennifer LR Freeman, Muralidhar Bondlela, Mustafa Guzel, Ravindra Reddy Yarragunta, Robert Carl Andrews, Santhosh Kalpathy, Stephen Thomas Davis, and Thomas Scott Yokum: US Patent # US 9175003, vTv Therapeutics, High Point, NC, Patent Application # 14603556, 03/11/2015.
  •  Synthesis of Substituted Pyridines from 1,2-Nucleophilic Addition Products of Functionalized N-Acyl-2,3-dihydropyridones; Mustafa Guzel, Joshua Watts, Matthew McGilvary, Marcus Wright, and Sezgin Kiren; Tetrahedron Letters, volume: 56, number: 38, (2015), p:5872. doi:10.1016/j.tetlet.2015.07.045.
  • “Estimation of Octanol-Water Partition Coefficient Using Cationic Gemini Surfactants by Micellar Electrokinetic Chromatography’; Mustafa Guzel, Cevdet Akbay, Yatzka Hoyos , David H. Ahlstrom; Journal of Chromatography and Separation Techniques, volume: 6, number: 4, (2015), p-. doi:10.4172/2157- 7064.1000275.
  • “Induction of Heme Oxygenase I (HMOX1) by HPP-4382: A novel modulator of Bach-1 activity”; Otis Attucks, Kimberly Jasmer, Mark Hannink, Jareer Kassis, Zhenping Zhong, Suparna Gupta, Sam Victory, Mustafa Guzel, Dharma Polisetti, Robert Andrews, Adnan Mjalli, and Matthew Kostura; PLoSOne, 9, 7, (2014), p:1-12, e101044.
  • “Synthesis of Azabridged Bicyclic Ring Systems by Intramolecular Sakurai Reactions“; Mustafa Guzel, Robert Smitherman, and Sezgin Kiren; Tetrahedron Letters, manuscript submitted, 2014.
  • “Substituted Pyran Derivatives Useful as Antitumor Agents“; Mustafa Guzel, Devi Reddy, Rongyuan Xie, Dharma R. Polisetti, Stephen Davis, Soumya Sahoo, Hassan El Abdelloui, and Adnan M. M. Mjalli; High Point Pharmaceuticals Inc., High Point, NC, Patent #US 61/892,053, 2013.
  • “Substituted Fused Oxazoline Derivatives Useful as Antitumor Agents“; Mustafa Guzel, Devi Reddy, Rongyuan Xie, Dharma R. Polisetti, Soumya Sahoo, Stephen Davis, Mohan Rao, Kalpathy Santhosh, and Adnan M. M. Mjalli; High Point Pharmaceuticals Inc., High Point, NC, Patent #US 61/892,018, 2013.
  • “Characterization and application of molecular binary mixed molecular micelles of sodium10-undecenyl sulfate and sodium N-undecenyl leucinate as pseudostationary phases in micellar electrokinetic chromatography“; Cevdet Akbay, Hamid H. Ahmed, Hakan Arslan, Brittany Graham, and Mustafa Guzel; Talanta, 99, (2012), 441-449.
  • ” Study of chemical selectivity of binary mixed micelles of sodium 10-undecenyl sulfate and sodium N-undecenyl leucinate using linear solvation energy reletionships model“; Hamid H. Ahmed, David M. Ahlstrom, Hakan Arslan, Mustafa Guzel, and Cevdet Akbay; Journal of Chromatography A, 1236, (2012), 207-214.
  • “Novel Anticancer agents for hexokinase inhibition-Substituted cyclic-3-indole derivatives”; Mustafa Guzel, Rongyuan Xie, Dharma R. Polisetti, Robert C. Andrews, Adnan M. M. Mjalli, and Stephen Davis; High Point Pharmaceuticals Inc., High Point, NC, Application No: HPP 3018.001 US; patent manuscript submitted, 2013.
  • “Substituted Benzimidazole Derivatives and Methods of Use to Treat Oxidative Stress”; Mustafa Guzel, Sam Victory, Dharma R. Polisetti, Mathew Kostura, Adnan M. M. Mjalli, Otis Attucks, and Jareer Kassis; High Point Pharmaceuticals Inc., High Point, NC, Application No: HPP 3007.000 US; patent manuscript submitted, 2012.
  • “Substituted Pyridine derivatives, Pharmaceutical Compositions, and Methods of Use to Treat Oxidative Stress”; Mustafa Guzel, Sam Victory, Bapu Gaddam, Dharma R. Polisetti, Mathew Kostura and Adnan M. M. Mjalli; High Point Pharmaceuticals Inc., High Point, NC, Patent # WO 2011/022216, (02, 24, 2011).
  • “Oxadiazoanthracene Compounds, for Treatments of Diabetes”; Scott T. Yokum, Mustafa Guzel, Kalpathy C. Santhosh, Dharma R. Polisetti, Daniel P. Christen, Adnan M. Mjalli, and Stephen T. Davis; TransTech Pharma Inc., High Point, NC, , Patent # US 2011/7906507 (03, 15, 2011).
  • “In Silico Ligand-Receptor Docking of Potentially Selective Butyrylcholinesterase Inhibitors Structurally Related to the Marine Natural Product Debromoflustramine B”; Miguel O. Mitchell, Robert W. Figliozzi and Mustafa Guzel;Medicinal Chemistry, Volume 6, Number 3, 2010, 141-143.
  • “Substituted Pyridine derivatives, Pharmaceutical Compositions, and Methods of Use to Treat Oxidative Stress”; Mustafa Guzel, Sam Victory, Bapu Gaddam, Dharma R. Polisetti, Mathew Kostura and Adnan M. M. Mjalli; High Point Pharmaceuticals Inc., High Point, NC, Patent # US 2010/044508, (05, 08, 2010).
  • “Mandelic Acid Derivatives and Preparation Thereof”; Mustafa Guzel, Scott T. Yokum, and Dharma R. Polisetti; TransTech Pharma Inc., High Point, NC, Patent # US 2010/0036150, (02,11, 2010).
  • “Oxadiazoanthracene Compounds, Compositions of Oxadiazoanthracene Compounds and Methods of Treatment Using the Same”; Scott T. Yokum, Mustafa Guzel, Kalpathy C. Santhosh, Dharma R. Polisetti, Daniel P. Christen, Adnan M. Mjalli, and Stephen T. Davis; TransTech Pharma Inc., High Point, NC, , Patent # US 2010/0324033 (12, 23, 2010).
  • “Substituted Azoanthracene Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof”; Mustafa Guzel, Scott T. Yokum, Kalpathy C. Santhosh, Dharma R. Polisetti, Chris Behme, Adnan M. Mjalli, and Stephen T. Davis”; TransTech Pharma Inc., High Point, NC, Patent # WO 2010/4824 (07, 10, 2010).
  • “Tricyclic Compounds as Modulators of TNF-a Synthesis”; Mustafa Guzel, Mathew Kostura, Adnan M. Mjalli, Bapu Gaddam, and Dharma R. Polisetti; TransTech Pharma Inc., High Point, NC, Patent # US 2010/0190808 (07, 29, 2010).
  • “Oxadiazoanthracene Compounds, for Treatments of Diabetes”; Scott T. Yokum, Mustafa Guzel, Kalpathy C. Santhosh, Dharma R. Polisetti, Daniel P. Christen, Adnan M. Mjalli, and Stephen T. Davis; TransTech Pharma Inc., High Point, NC, , Patent # WO 2009/111700 (11, 09, 2009).
  • “Aryl Carbonyl Derivatives as Therapeutic Agents-Part-II”; Kalpaty C. Santhosh, Mustafa Guzel, Dharma R. Polisetti, Adnan M. Mjalli, and Robert C. Andrews; TransTech Pharma Inc., High Point, NC, Patent # US 2009/7541373 (06, 02, 2009).
  • “Tricyclic Compounds as Modulators of TNF-a Synthesis as PDE4 Inhibitors”; Mustafa Guzel, Mathew Kostura, Adnan M. Mjalli, Bapu Gaddam, and Dharma R. Polisetti; TransTech Pharma Inc., High Point, NC, Patent # WO 2009/094528, (07, 30, 2009)