Prof. Miski, presented at the International Symposium on the Chemistry

There were more than 200 scientists from France, Russia, China, Uzbekistan, Kazakhstan, Iran, Algeria and Turkey attended the meeting. There were several topics discussed during the meeting including the development of medicines from natural products, and chemistry and bio-activities of natural compounds. The title Prof. Dr. Mahmud Miski was "Chemistry, Biology and Pharmacology of the Sesquiterpenes Isolated from Ferula Species Growing in Anatolia," he specifically discussed the anticancer, anti...
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Assoc Prof.Dr. Mustafa GUZEL

Contact: mguzel@medipol.edu.tr Dr. Güzel graduated from Hacettepe University School of Engineering with a B. Sc degree in Chemistry in 1987 and completed his M. Sc. and Ph. D. Degrees on Medicinal Chemistry at Clemson University, Clemson, SC in 1996 and 2001 respectively. He worked as organic lab coordinator at Northeastern University and later joined to ArQule Inc.as Sr. Synthetic Organic Chemist upon his graduation. He then joined to TransTech Pharma Inc, in High Point, NC and assumed v...
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Şükran OZDATLI, Ph. D. Student

Contact: sozdatli@medipol.edu.tr She has finished her bachelor’s degree from Faculty of Pharmacy of Yeditepe University at 2013. She is currently a PhD student in Toxicology Department of Faculty of Pharmacy of Yeditepe University. She completed her graduation study with a thesis entitled “Effects of Concomitant Usage of Paracetamol and N-Acetylcysteine to Prevent Possible Paracetamol Toxicity” and also worked as Research Assistant in Yeditepe University. During this time, she studied abo...
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GRG Research Interests

In our lab we mainly focus on drug discovery and development of various therapeutic targets such as Neurodegenerative Disorders (ALS, Alzheimer’s and Parkinson’s disease etc.), and Inflammatory Disorders (COPD, RA), GPCRs for the treatment of Diabetic Disorders (NIDDM), Cancer, Cardiovascular Disorders, Obesity, and other Metabolic Disorders.   We are also very interested in research and development with an emphasis in design and synthesis of both symmetric and asymmetric orga...
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Projects

Novel Ghrelin Antagonists for treatment of Obesity. Novel Sigma-1 Receptor Agonists for treatment of Neurodegenerative Diseases. Novel A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s disease and SAR of the new Preladenant analogs. Discovery of novel Excitatory Amino Acid Transporter-2 (EAAT2) modulators for the treatment of ALS and other neurodegenerative disorders. Regulation of cancer cell metabolism: Targeting cancer metabolism as an alternative therapeutic trea...
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Patents & Publications

"Induction of Heme Oxygenase I (HMOX1) by HPP-4382: A novel modulator of Bach-1 activity”; Otis Attucks, Kimberly Jasmer, Mark Hannink, Jareer Kassis, Zhenping Zhong, Suparna Gupta, Sam Victory, Mustafa Guzel, Dharma Polisetti, Robert Andrews, Adnan Mjalli, and Matthew Kostura; PLoSOne, 9, 7, (2014), p:1-12, e101044. "Synthesis of Azabridged Bicyclic Ring Systems by Intramolecular Sakurai Reactions"; Mustafa Guzel, Robert Smitherman, and Sezgin Kiren; Tetrahedron Letters, manuscript sub...
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