Dr. Shazia Iqbal, Postdoctoral Fellow

Contact: shazia_hena@yahoo.com

Shazia Iqbal grew up in Karachi, Pakistan, and obtained her BS degree in chemistry from university of Karachi, Pakistan. She completed her Ph.D. on Organic Chemistry at HEJ Research institute of Chemistry (ICCBS), university of Karachi, Karachi, Pakistan in April 2019. She worked on two key projects in her M.phil leading to Ph.D., in one, she developed synthetic strategies and prepared analogues of medicinally important scaffolds via regioselective copper catalyzed click reaction and their biological activity evaluation. In second project, she worked on the syntheses of structurally diverse electrophilic benzofused exo- and endocyclic acyl sultam scaffolds via reaction pairing CAP/CP strategies and in vitro reactivity profiling studies using both 19F- and 1H-NMR spectroscopy.Her areas of research include development of synthetic strategies to make small molecules as lead compounds, drug design and discovery, as well as medicinal chemistry. She has got a wonderful experience during her PhD as a visiting research scholar at the University of Kansas, USA. Recently, joined as postdoctoral fellow in GRG lab at the Istanbul Medipol University.

ACHIEVEMENTS:

  • Awarded 1st Prize in poster competition and presentation held during November 4-6, 2018, “2nd International Symposium on Natural Products for the Future (ISNPF-2)”, poster entitled, “Synthesis of New Triazole Linked Tricyclic Compounds as Potent ROS Inhibitors”
  • Got UBF (Umaer Basha Foundation) scholarship for advance studies and research opportunity at the University of Kansas, Lawrence, KS,

POSTER PRESENTATIONS & PUBLICATIONS:

  • Iqbal, S.; Khan, M.; Jabeen, A.; Faheem, A.; Choudhary, M. I.; Basha, F. Z. 2nd International Symposium on Natural Products for the Future (ISNPF-2) at ICCBS, University of Karachi, Karachi, SD, Pakistan (Nov 4-6, 2018). Poster: Synthesis of New Triazole Linked Tricyclic Compounds as Potent ROS Inhibitors.
  • Ullah, S.; Iqbal, S.; A.; Wahab, A.; Choudhary, M. I. 14th International Symposium on Natural Product Chemistry (ISNPC-14) at University of Karachi, Karachi, SD, Pakistan (Nov 6-8, 2018). Poster: Bicarbazole Tethered Bistriazoles: A New Class of α-Glucosidase Inhibitors.
  • Iqbal, S.; Khan, M.; Zang, Q.; Clay, C.; Gao, E.; Loh, J.; Asad, N.; Kyung Lee. Y.; Hanson, P. R. Midwest Regional Meeting (MWRM), Lawrence, KS, US (October 18-20, 2017). Poster: Design, Synthesis and Reactivity Profiling of Cysteine-Reactive Electrophilic Acyl Sultams.
  • Clay, C.; Jun, J. H.; Iqbal, S; Hanson, P. R. 52nd Midwest Regional Meeting of the American Chemical Society, Lawrence, KS, United States, October 18-20 (2017). Poster: Thiol modulation: Activity profiling of sulfur containing covalent modifiers and known drugs.
  • Clay, C. D.; Jun, J. H.; Iqbal, S.; Cassity, A.; Jha, J. S.; Hanson, P. R. 254th ACS National Meeting & Exposition, Washington, DC, USA, August 20-24, (2017). Poster: Use of 19F NMR to monitor thiol reactions of sultams, sulfonamides and known drugs.
  • Iqbal, S.; Khan, M.; Zang, Q.; Gao, E.; Loh, J.; Asad, N.; Hanson, P. R. 22nd Annual Chemical Biology Symposium, University of Kansas, Lawrence, KS, US (Mar 30, 2017). Poster: Electrophilic Sultams: Guided Diversity Oriented Synthesis to Develop Chemical Modifiers of N-Acetyl Cysteine.
  • Iqbal, S.; Khan, M.; Zang, Q.; Gao, E.; Loh, J.; Asad, N.; Hanson, P. HBC Science Talks at University of Kansas, Lawrence, KS, US (Feb 19, 2017). Poster: Electrophilic Sultams: Synthesis and Reactivity.
  • Iqbal, S.; Khan, M. A.; Javaid, K.; Sadiq, R. Fazal-ur-Rehman, S.; Choudhary, M. I.; Basha, F. Z. New carbazole linked 1,2,3-triazoles as highly potent non-sugar α-glucosidase inhibitors, Chem., 2017, 74, 72-81.
  • Shaikh, N. N.; Iqbal, S.; Khan, M. A.; Syed, N.; Moin, S. T.; Choudhary, M. I.; Basha, F. Z. Carbazole Linked 1,2,3-triazoles: In vitro β-Glucuronidase Inhibitory Potential, Kinetics, and Molecular Docking Studies, Chemistry Select, 2019, 4, 1– 10.
  • Iqbal, S.; Khan, M. A.; Zulqarnain; Jabeen, A.; Faheem, A.; Saba; Basha, F. Z. Synthesis of New Bicarbazole–Linked Triazoles as Potent and Non–cytotoxic Reactive Oxygen Species (ROS) Inhibitors, Synthetic Communications (LSYC-2018-12838.R1) Accepted, 2019.
  • Rahman, S., Zainab, Khan, M. A., Iqbal, S., Jabeen, A., Saba, Basha, F. Z. Identification of Pyrazole Analogues as Reactive Oxygen Species (ROS) Inhibitors, Journal of the Chemical Society of Pakistan J. Pharm. Sci., 2019, 32 (3), 285-1291.
  • Saba, Khan, M. A.; Iqbal, S. Antioxidant and lipoxygenase inhibition studies of 4-(4-bromophenyl)-2,2′-bipyridine and its metal complexes – Synthesis, Characterization and Biological Screening, J. Pharm. Sci., 2019 (Accepted).
  • Khan, M. A.; Iqbal, S.; Zang, Q.; Clay, C.; Gao, E.; Basha, F. Z.; Hanson, P. R. Cysteine Reactivity Profiling Studies of Electrophilic Acetyl Sultams using 19F-NMR Analysis, Organic & Biomolecular Chemistry (Submitted).
  • Batool, F.; Khan, M. A.; Shaikh, N. N.; Iqbal, S.; Choudhary, M. I.; Basha, F. Z. New Benzamide Analogues of Meteronidazole-tethered Triazole as Novel Non-sugar based Inhibitors of β-Glucuronidase In vitro, Chem., (Submitted).
  • Cassity, A.; Ganguly, A.; Javed, S.; Jun, J.; Iqbal, S.; Khan, M.; Thomas, V.; Dissanayke, G.; Basha, F.; Hanson, P. R. Advances in S- and P- Electrophilic Probes. (Mini Review in advance stage).
  • Zang, Q.; Khan, M. A.; Iqbal, S.; Gao, E.; Basha, F. Z.; Hanson, P. R. The Synthesis of Endo-N-Acyl Sultams via a One-pot SNAr, Coupling Sequence (Advance stage).
  • Iqbal, S.; Khan, M. A.; Jabeen, A.; Faheem, A.; Yousuf, S.; Basha, F. Z. Synthesis, and Structure–Activity Relationship of N9–, and C7–Linked Triazole Analogues of Harmine as New Class of ROS Inhibitors (Advance Stage).
  • Arshad, F.; Iqbal, S.; Khan, M. A.; Choudhary, M. I.; Basha, F. Z. Carbazole and Biscarbazole Linked–Triazoles as New Class of Non-Sulfonamide Carbonic Anhydrase–II Inhibitors (Advance stage).