GRG Research Interests

In our lab we mainly focus on drug discovery and development of various therapeutic targets such as Neurodegenerative Disorders (ALS, Alzheimer’s and Parkinson’s disease etc.), and Inflammatory Disorders (COPD, RA), GPCRs for the treatment of Diabetic Disorders (NIDDM), Cancer, Cardiovascular Disorders, Obesity, and other Metabolic Disorders.   We are also very interested in research and development with an emphasis in design and synthesis of both symmetric and asymmetric orga...
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Projects

Novel Ghrelin Antagonists for treatment of Obesity. Novel Sigma-1 Receptor Agonists for treatment of Neurodegenerative Diseases. Novel A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s disease and SAR of the new Preladenant analogs. Discovery of novel Excitatory Amino Acid Transporter-2 (EAAT2) modulators for the treatment of ALS and other neurodegenerative disorders. Regulation of cancer cell metabolism: Targeting cancer metabolism as an alternative therapeutic trea...
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Patents & Publications

“Novel Strategies for the Synthesis of A2A Adenosine Receptor Antagonist Analogs”; Şükran Özdatlı, Hanife Pekel, Bilgesu Onur Sucu, and Mustafa Guzel; Tetrahedron Letters, volume: 59, number: 3, (2019), manuscript in preparation. “Antifungal and Antibacterial Activity of Some Marine Invertebrates from Turkish Coastlines”; Ayse Esra Karadag, Hajar Heydari, Ismail Korpe, Belma Konuklugil, Betul Giray, and Mustafa Guzel; Frontiers in Microbiology, 2019, manuscript submitted. “Novel Hetero...
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